Hematology and Blood Disorders

Neuro-hematology is study of the variations in the composition of the blood occurring in diseases of the nervous system.
A wide spectrum of hematologic disorders causes the central and peripheral nervous system. These disorders include like

• Porphyria
• Thrombotic thrombocytopenic purpura-hemolytic uremic syndromes
• Sickle cell disease
• Plasma cell dyscrasias
• Monoclonal gammopathy
• Primary systemic amyloidosis
• Primary systemic amyloidosis
• Waldonstrom’s macroglobulinemia
• Myeloproliferative syndromes
• Cryoglobulinemia, and polycythemia vera

Some, like porphyria, cause both central and peripheral nervous system manifestations containing sensory/motor peripheral neuropathy, dysautonomia, pain, seizures, and abdominal pain.
Others such as sickle cell disease primarily affect the brain and cause both clinically apparent strokes associated with a vasculopathy of large intracranial blood vessels, as well as a smaller amount obvious micro strokes that cause progressive cognitive decline if not treated.